Magnetic susceptibility and R2* of myocardial reperfusion injury at 3T and 7T.

ABSTRACT:

Purpose

Magnetic susceptibility (Δχ) alterations have shown association with myocardial infarction (MI) iron deposition, yet there remains limited understanding of the relationship between relaxation rates and susceptibility or the effect of magnetic field strength. Hence, Δχ and R2∗ in MI were compared at 3T and 7T.

Methods

Subacute MI was induced by coronary artery ligation in male Yorkshire swine. 3D multiecho gradient echo imaging was performed at 1-week postinfarction at 3T and 7T. Quantitative susceptibility mapping images were reconstructed using a morphology-enabled dipole inversion. R2∗ maps and quantitative susceptibility mapping were generated to assess the relationship between R2∗ , Δχ, and field strength. Infarct histopathology was investigated.

Results

M

SUBMITTER: Moon BF 

PROVIDER: S-EPMC9067599 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature