Comparative analysis of web-based programs for single amino acid substitutions in proteins.

ABSTRACT: Single amino-acid substitution in a protein affects its structure and function. These changes are the primary reasons for the advent of many complex diseases. Analyzing single point mutations in a protein is crucial to see their impact and to understand the disease mechanism. This has given many biophysical resources, including databases and web-based tools to explore the effects of mutations on the structure and function of human proteins. For a given mutation, each tool provides a score-based outcomes which indicate deleterious probability. In recent years, developments in existing programs and the introduction of new prediction algorithms have transformed the state-of-the-art protein mutation analysis. In this study, we have performed a systematic study of the most commonly used mutatio

SUBMITTER: Choudhury A 

PROVIDER: S-EPMC9067658 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature