The intrinsically photosensitive retinal ganglion cell (ipRGC) mediated pupil response in young adult humans with refractive errors.

ABSTRACT:

Purpose

The intrinsically photosensitive retinal ganglion cells (ipRGCs) signal environmental light, with axons projected to the midbrain that control pupil size and circadian rhythms. Post-illumination pupil response (PIPR), a sustained pupil constriction after short-wavelength light stimulation, is an indirect measure of ipRGC activity. Here, we measured the PIPR in young adults with various refractive errors using a custom-made optical system.

Methods

PIPR was measured on myopic (-3.50 ± 1.82 D, n = 20) and non-myopic (+0.28 ± 0.23 D, n = 19) participants (mean age, 23.36 ± 3.06 years). The right eye was dilated and presented with long-wavelength (red, 625 nm, 3.68 × 10¹⁴ photons/cm²/s) and short-wavelength (blue, 470 nm, 3.24 × 10¹⁴ photo

SUBMITTER: Chakraborty R 

PROVIDER: S-EPMC9068560 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature