Accuracy of central neuro-imaging review of DIPG compared with histopathology in the International DIPG Registry.

ABSTRACT:

Background

Diffuse intrinsic pontine glioma (DIPG) remains a clinico-radiologic diagnosis without routine tissue acquisition. Reliable imaging distinction between DIPG and other pontine tumors with potentially more favorable prognoses and treatment considerations is essential.

Methods

Cases submitted to the International DIPG registry (IDIPGR) with histopathologic and/or radiologic data were analyzed. Central imaging review was performed on diagnostic brain MRIs (if available) by two neuro-radiologists. Imaging features suggestive of alternative diagnoses included nonpontine origin, <50% pontine involvement, focally exophytic morphology, sharply defined margins, and/or marked diffusion restriction throughout.

Results

Among 286 patients with pathology from biopsy and/o

SUBMITTER: Lazow MA 

PROVIDER: S-EPMC9071293 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature