Overproduction of lipopeptide biosurfactant by Aneurinibacillus thermoaerophilus HAK01 in various fed-batch modes under thermophilic conditions.

ABSTRACT: An efficient lipopeptide biosurfactant (BS) producer, Aneurinibacillus thermoaerophilus HAK01, was isolated from municipal landfill sites. The strain was able to produce about 4.9 g L^-1 lipopeptide at a thermophilic temperature of 45 °C. After optimization of culture component concentrations using the response surface method, the main focus is to find the most appropriate fed-batch strategy to enhance lipopeptide production by the HAK01 strain. For this purpose, four fed-batch strategies including (a) pH-stat mode, (b) constant feeding rate strategy, (c) DO-stat mode, and (d) combined feeding strategy were designed. The production of BS was increased systematically from 4.9 g L^-1 in batch mode to 5.9, 7.1, 8.8 and 11.2 g L^-1 in each fed-batch mode, r

SUBMITTER: Hajfarajollah H 

PROVIDER: S-EPMC9072080 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature