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DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2'-bipyridine based binuclear ternary transition metal complexes.

ABSTRACT: In the present contribution, new binuclear ternary complexes; [M2(bpy)4L](ClO4)4 (M = Co(ii) (1) and Ni(ii) (2); bpy = 2,2'-bipyridine; L = 1,1'-(hexane-1,6-diyl)bis[2-(pyridin-2-yl)1H-benzimidazole] and [Cu2(bpy)2(OH2)2L](BF4)4 (3) were synthesized, characterized and screened for their antimicrobial activity and cytotoxicity against human liver carcinoma cells (HepG-2) as well as non-malignant human embryonic kidney cells (HEK-293). The structural studies were complemented by density functional theory (DFT) calculations. DNA binding of 1-3 was spectrophotometrically studied. The DNA cleavage ability of 1-3 towards the supercoiled plasmid DNA (pBR322 DNA) was examined through gel electrophoresis. Compound 3 has the highest cytotoxic activity (IC50 = 3.5 μg mL-1) against HepG-2 among the investigated complexes and is non cytotoxic to noncancerous HEK-293. Complexes (1 and 2) exhibited toxicity to HEK-293 with IC50 values of 30.3 and 23.5 μg mL-1 in that order. While compound 1 showed antifungal activity against Cryptococcus neoformans, complex 2 exhibited its toxicity against Candida albicans.

SUBMITTER: Mansour AM 

PROVIDER: S-EPMC9072361 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2'-bipyridine based binuclear ternary transition metal complexes.

Mansour Ahmed M AM   Ragab Mona S MS  

RSC advances 20190930 53

In the present contribution, new binuclear ternary complexes; [M<sub>2</sub>(bpy)<sub>4</sub>L](ClO<sub>4</sub>)<sub>4</sub> (M = Co(ii) (1) and Ni(ii) (2); bpy = 2,2'-bipyridine; L = 1,1'-(hexane-1,6-diyl)bis[2-(pyridin-2-yl)1<i>H</i>-benzimidazole] and [Cu<sub>2</sub>(bpy)<sub>2</sub>(OH<sub>2</sub>)<sub>2</sub>L](BF<sub>4</sub>)<sub>4</sub> (3) were synthesized, characterized and screened for their antimicrobial activity and cytotoxicity against human liver carcinoma cells (HepG-2) as well as  ...[more]

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