DNA/lysozyme binding propensity and nuclease properties of benzimidazole/2,2'-bipyridine based binuclear ternary transition metal complexes.

ABSTRACT: In the present contribution, new binuclear ternary complexes; [M₂(bpy)₄L](ClO₄)₄ (M = Co(ii) (1) and Ni(ii) (2); bpy = 2,2'-bipyridine; L = 1,1'-(hexane-1,6-diyl)bis[2-(pyridin-2-yl)1H-benzimidazole] and [Cu₂(bpy)₂(OH₂)₂L](BF₄)₄ (3) were synthesized, characterized and screened for their antimicrobial activity and cytotoxicity against human liver carcinoma cells (HepG-2) as well as non-malignant human embryonic kidney cells (HEK-293). The structural studies were complemented by density functional theory (DFT) calculations. DNA binding of 1-3 was spectrophotometrically studied. The DNA cleavage ability of 1-3 towards the supercoiled plasmid DNA (pBR322 DNA) was examined throug

SUBMITTER: Mansour AM 

PROVIDER: S-EPMC9072361 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature