A strained alkyne-containing bipyridine reagent; synthesis, reactivity and fluorescence properties.

ABSTRACT: We report the synthesis of a bipyridyl reagent containing a strained alkyne, which significantly restricts its flexibility. Upon strain-promoted alkyne-azide cycloaddition (SPAAC) with an azide, which does not require a Cu catalyst, the structure becomes significantly more flexible and an increase in fluorescence is observed. Upon addition of Zn(ii), the fluorescence is enhanced further. The reagent has the potential to act as a fluorescent labelling agent with azide-containing substrates, including biological molecules.

SUBMITTER: Forshaw S 

PROVIDER: S-EPMC9074932 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature