Single-cell dual-omics reveals the transcriptomic and epigenomic diversity of cardiac non-myocytes.

ABSTRACT:

Aims

The precise cellular identity and molecular features of non-myocytes (non-CMs) in a mammalian heart at a single-cell level remain elusive. Depiction of epigenetic landscape with transcriptomic signatures using the latest single-cell multi-omics has the potential to unravel the molecular programs underlying the cellular diversity of cardiac non-myocytes. Here, we characterized the molecular and cellular features of cardiac non-CM populations in the adult murine heart at the single-cell level.

Methods and results

Through single-cell dual omics analysis, we mapped the epigenetic landscapes, characterized the transcriptomic profiles and delineated the molecular signatures of cardiac non-CMs in the adult murine heart. Distinct cis-regulatory elements and trans-acting factors

SUBMITTER: Wang L 

PROVIDER: S-EPMC9074971 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature