Characteristics of Anaplastic Oligodendrogliomas Short-Term Survivors: A POLA Network Study.

ABSTRACT:

Background

Anaplastic oligodendrogliomas IDH-mutant and 1p/19q codeleted (AO) occasionally have a poor outcome. Herein we aimed at analyzing their characteristics.

Methods

We retrospectively analyzed the characteristics of 44 AO patients with a cancer-specific survival <5 years (short-term survivors, STS) and compared them with those of 146 AO patients with a survival ≥5 years (classical survivors, CS) included in the POLA network.

Results

Compared to CS, STS were older (P = .0001), less frequently presented with isolated seizures (P < .0001), more frequently presented with cognitive dysfunction (P < .0001), had larger tumors (P = .= .003), a higher proliferative index (P = .= .0003), and a higher number of chromosomal arm abnormalities (P = .= .02). Regarding treatme

SUBMITTER: Garnier L 

PROVIDER: S-EPMC9074983 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature