Dataset Information
Association of MTHFR, BMP4, TGFA and IRF6 Polymorphisms with Non-Syndromic Cleft lip and Palate in North Indian Patients.
Ontology highlight
ABSTRACT: Background
Non-Syndromic Cleft Lip and Palate (NSCL/P) is a multifactorial birth defect. The world-wide prevalence of NSCL/P is 1 in 1000 live births; it differs with race, ethnicity and gender. The aim of the present study was to find out the status of candidate gene polymorphisms in NSCL/P cases and its association in phenotype of the patients.Methods
We have screened five polymorphisms in four candidate genes MTHFR (rs1801133, rs1801131) BMP4 (rs17563), TGFA (rs1146297) and IRF6 (rs2235371) by restriction fragment length polymorphism and results were validated by Sanger sequencing. Our dataset consists of 200 NSCL/P cases and 200 healthy controls from the Indian population. Statistical data analysis was performed by SPSS software.Results
MTHFR (rs1801133), BMP4 (rs175563) and TGFA (rs11466297) gene polymorphisms showed significant association with NSCL/P and act as a risk factor in the Indian population (p=<0.05). However, MTHFR (rs1801131), and IRF6 (rs2235371) gene polymorphisms did not show significant association with NSCL/P in the Indian population.Conclusion
The result of the study suggests an association between MTHFR (rs1801133), BMP4 (rs175563) and TGFA (rs11466297) polymorphisms with NSCL/P in Indian population.
SUBMITTER: Avasthi KK
PROVIDER: S-EPMC9077655 | biostudies-literature | 2022 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
Association of <i>MTHFR, BMP4, TGFA</i> and <i>IRF6</i> Polymorphisms with Non-Syndromic Cleft lip and Palate in North Indian Patients.
Avicenna journal of medical biotechnology 20220401 2
<h4>Background</h4>Non-Syndromic Cleft Lip and Palate (NSCL/P) is a multifactorial birth defect. The world-wide prevalence of NSCL/P is 1 in 1000 live births; it differs with race, ethnicity and gender. The aim of the present study was to find out the status of candidate gene polymorphisms in NSCL/P cases and its association in phenotype of the patients.<h4>Methods</h4>We have screened five polymorphisms in four candidate genes <i>MTHFR</i> (rs1801133, rs1801131) <i>BMP4</i> (rs17563), <i>TGFA</ ...[more]