Ontology highlight
ABSTRACT:
SUBMITTER: Suo Z
PROVIDER: S-EPMC9077761 | biostudies-literature | 2018 Jan
REPOSITORIES: biostudies-literature
Suo Zili Z Sun Qiaomei Q Yang Hongqin H Tang Peixiao P Gan Ruixue R Xiong Xinnuo X Li Hui H
RSC advances 20180126 9
Trametinib is a novel anticancer drug for treating metastatic cutaneous melanoma. The present study probed into the binding of trametinib to human serum albumin (HSA) through spectroscopy methods and molecular simulations. Trametinib could quench the fluorescence of HSA through static quenching which could be probed <i>via</i> fluorescence spectroscopy and time-resolved fluorescence. Thermodynamic parameters and docking results indicated that hydrogen bonds and van der Waals forces play crucial ...[more]