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A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells.

ABSTRACT: A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D2 via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D2 and could be monitored by cellular imaging.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9079131 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells.

Zhang Hengrui H   Fang Zhijie Z  

RSC advances 20180322 21

A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D<sub>2</sub> <i>via</i> a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D<sub>2</sub> and could be monitored by cellular imaging. ...[more]

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