A novel glutathione-triggered theranostic prodrug for anticancer and imaging in living cells.

ABSTRACT: A novel theranostic prodrug was designed and synthesized by conjugating a naphthalimide derivative with vitamin D₂ via a disulfide linker. The prodrug featured a highly selective detection process for glutathione (GSH) and showed a red-shifted fluorescence within 30 min. Notably, it also exhibited antitumor activity similar to vitamin D₂ and could be monitored by cellular imaging.

SUBMITTER: Zhang H 

PROVIDER: S-EPMC9079131 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature