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Cobalt-catalyzed C(sp³)-H/C(sp²)-H oxidative coupling between alkanes and benzamides.

ABSTRACT: A direct cobalt-catalyzed oxidative coupling between C(sp²)-H in unactivated benzamides and C(sp³)-H in simple alkanes, ethers and toluene derivatives was explored. This protocol achieves direct C-C formation without using alkyl or aryl halide surrogates and exhibits high practicality with ample substrate scope. The method provides a new way to construct linear and five- or six-membered ring moieties in bioactive molecules.

SUBMITTER: Li S

PROVIDER: S-EPMC9079668 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Cobalt-catalyzed C(sp3)-H/C(sp2)-H oxidative coupling between alkanes and benzamides.

Li Shuangjie S Wang Bao B Dong Guangyu G Li Chunpu C Liu Hong H

RSC advances 20180410 24

A direct cobalt-catalyzed oxidative coupling between C(sp2)-H in unactivated benzamides and C(sp3)-H in simple alkanes, ethers and toluene derivatives was explored. This protocol achieves direct C-C formation without using alkyl or aryl halide surrogates and exhibits high practicality with ample substrate scope. The method provides a new way to construct linear and five- or six-membered ring moieties in bioactive molecules. ...[more]

PMID: 35542514

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