Comparative lipidomic profiling of the human commensal bacterium Propionibacterium acnes and its extracellular vesicles.

ABSTRACT: Propionibacterium acnes is a lipophilic commensal bacterium mainly found on the skin and in the gastrointestinal tract. Pathophysiological effects of P. acnes have recently been reported not only in acne progression but in various diseases. As an emerging mode of bacterial communication, extracellular vesicles (EVs) have been demonstrated to conduct critical pathophysiological functions. To provide information on P. acnes lipid composition for the first time, we conducted a comparative lipidomic analysis of P. acnes and P. acnes EVs and identified 214 lipids with high confidence using triplicated liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) analyses. P. acnes EVs contained substantially more PCs, DGs, PAs, PEs, LPAs, LPCs, a

SUBMITTER: Jeon J 

PROVIDER: S-EPMC9080044 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature