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Preparation and photo-induced activities of water-soluble amyloid β-C₆₀ complexes.

ABSTRACT: We have shown that fullerene (C₆₀) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril structures are considered to be associated with Alzheimer's disease. The water-solubility of fullerene arises from the generation of a nanosized complex between fullerene and the monomer species of Aβ40 (Aβ40-C₆₀). The prepared Aβ40-C₆₀ exhibits photo-induced activity with visible light to induce the inhibition of Aβ40 fibrillation and the cytotoxicity for cultured HeLa cells. The observed photo-induced phenomena result from the generation of singlet oxygen via photoexcitation, inducing oxidative damage to Aβ40 and HeLa cells. The oxidized Aβ40 following photoexcitation of Aβ40-C₆₀ was confirmed by mass spectrometry.

SUBMITTER: Hasunuma N

PROVIDER: S-EPMC9080474 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature

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Preparation and photo-induced activities of water-soluble amyloid β-C60 complexes.

Hasunuma Naoki N Kawakami Masahiro M Hiramatsu Hirotsugu H Nakabayashi Takakazu T

RSC advances 20180516 32

We have shown that fullerene (C60) becomes soluble in water by mixing fullerene and amyloid β peptide (Aβ40) whose fibril structures are considered to be associated with Alzheimer's disease. The water-solubility of fullerene arises from the generation of a nanosized complex between fullerene and the monomer species of Aβ40 (Aβ40-C60). The prepared Aβ40-C60 exhibits photo-induced activity with visible light to induce the inhibition of Aβ40 fibrillation and the cyt ...[more]

PMID: 35542080

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