Water-Soluble Fullerene C₆₀ Derivatives Are Effective Inhibitors of Influenza Virus Replication.

ABSTRACT: The influenza virus genome features a very high mutation rate leading to the rapid selection of drug-resistant strains. Due to the emergence of drug-resistant strains, there is a need for the further development of new potent antivirals against influenza with a broad activity spectrum. Thus, the search for a novel, effective broad-spectrum antiviral agent is a top priority of medical science and healthcare systems. In this paper, derivatives based on fullerenes with broad virus inhibiting activities in vitro against a panel of influenza viruses were described. The antiviral properties of water-soluble fullerene derivatives were studied. It was demonstrated that the library of compounds based on fullerenes has cytoprotective activity. Maximum virus-inhibiting activity and minimum toxicity w

SUBMITTER: Sinegubova EO 

PROVIDER: S-EPMC10053623 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature