Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model.

ABSTRACT: Assisted Reproductive Technologies (ART) employ gamete/embryo handling and culture in vitro to produce offspring. ART pregnancies have an increased risk of low birth weight, abnormal placentation, pregnancy complications, and imprinting disorders. Embryo culture induces low birth weight, abnormal placental morphology, and lower levels of DNA methylation in placentas in a mouse model of ART. Whether preimplantation embryos at specific stages of development are more susceptible to these perturbations remains unresolved. Accordingly, we performed embryo culture for several discrete periods of preimplantation development and following embryo transfer, assessed fetal and placental outcomes at term. We observed a reduction in fetal:placental ratio associated with two distinct windows of p

SUBMITTER: Vrooman LA 

PROVIDER: S-EPMC9081528 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature