Structural modification of oridonin via DAST induced rearrangement.
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ABSTRACT:
SUBMITTER: Luo DD
PROVIDER: S-EPMC9085272 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Structural modification of oridonin <i>via</i> DAST induced rearrangement.
Luo Dong-Dong DD Peng Kai K Yang Jia-Yu JY Piyachaturawat Pawinee P Saengsawang Witchuda W Ao Lei L Zhao Wan-Zhou WZ Tang Yu Y Wan Sheng-Biao SB
RSC advances 20180820 52
A simple and efficient protocol was developed for the syntheses of oridonin analogues, <i>i.e.</i> 6,20-epoxy <i>ent</i>-kaurane diterpenoid analogues from oridonin <i>via</i> diethylaminosulfur trifluoride (DAST) promoted rearrangement, most of which exhibited superior anticancer activities compared with their precursor. ...[more]
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