Peroxisome-Derived Hydrogen Peroxide Modulates the Sulfenylation Profiles of Key Redox Signaling Proteins in Flp-In T-REx 293 Cells.

ABSTRACT: The involvement of peroxisomes in cellular hydrogen peroxide (H₂O₂) metabolism has been a central theme since their first biochemical characterization by Christian de Duve in 1965. While the role of H₂O₂ substantially changed from an exclusively toxic molecule to a signaling messenger, the regulatory role of peroxisomes in these signaling events is still largely underappreciated. This is mainly because the number of known protein targets of peroxisome-derived H₂O₂ is rather limited and testing of specific targets is predominantly based on knowledge previously gathered in related fields of research. To gain a broader and more systematic insight into the role of peroxisomes in redox signaling, new approaches are urgently neede

SUBMITTER: Lismont C 

PROVIDER: S-EPMC9086853 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature