A Systematic Screening of ADHD-Susceptible Variants From 25 Chinese Parents-Offspring Trios.

ABSTRACT: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent and heritable childhood behavioral disorders. Although a number of ADHD-susceptible regions had been identified, details about the variations of genes and their related patterns involved in ADHD are still lacking. In this study, we collected 25 Chinese parents-offspring trios, each of which consisted of a child diagnosed with ADHD and his/her unaffected parents, and analyzed the variations from whole-genome sequencing data. SNVs in reported ADHD-susceptible regions and on the genes whose functions were related to dopamine were screened, and we identified a set of variants with functional annotations which were specifically detected in ADHD children, including most SNVs in the gene coding region that might impair p

SUBMITTER: Li Q 

PROVIDER: S-EPMC9087589 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature