Microbial Translocation in the Context of Hepatitis B Infection and Hepatitis D Infection.

ABSTRACT:

Background

Increased microbial translocation (MT) into the systemic circulation is associated with liver disease progression. Microbial translocation has yet to be completely defined in chronic hepatitis B virus (HBV) and chronic hepatitis delta virus (HDV).

Methods

Our aim was to characterize MT and associated immune response in chronic HBV and HDV at various stages of disease. Serum from 53 HBV, 43 HDV, and 36 healthy control (HC) subjects was obtained. Subjects were categorized by aspartate aminotransferase-to-platelet ratio index into mild (<0.5), moderate, and severe (>1.0) disease. Cytokines, microbial products, and microbial deoxyribonucleic acid (DNA) levels were assessed in a single treatment-naive time point for each patient. Next-generation sequencing identified b

SUBMITTER: Townsend EC 

PROVIDER: S-EPMC9088508 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature