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Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.

ABSTRACT: Parasite-derived PVM-resident proteins are critical for complete parasite development inside hepatocytes, although the function of most of these proteins remains unknown. Here, we show that the upregulated in infectious sporozoites 4 (UIS4) protein, resident at the PVM, interacts with the host cell actin. By suppressing filamentous actin formation, UIS4 avoids parasite elimination. Host cell actin dynamics increases around UIS4-deficient parasites, which is associated with subsequent parasite elimination. Notably, parasite elimination is impaired significantly by the inhibition of host myosin-II, possibly through relieving the compression generated by actomyosin complexes at the host-parasite interface. Together, these data reveal that UIS4 has a critical role in the evasion of host defensive mechanisms, enabling hence EEF survival and development.

SUBMITTER: M'Bana V

PROVIDER: S-EPMC9095750 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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<i>Plasmodium</i> parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.

M'Bana Viriato V Lahree Aparajita A Marques Sofia S Slavic Ksenija K Mota Maria M MM

iScience 20220422 5

Parasite-derived PVM-resident proteins are critical for complete parasite development inside hepatocytes, although the function of most of these proteins remains unknown. Here, we show that the upregulated in infectious sporozoites 4 (UIS4) protein, resident at the PVM, interacts with the host cell actin. By suppressing filamentous actin formation, UIS4 avoids parasite elimination. Host cell actin dynamics increases around UIS4-deficient parasites, which is associated with subsequent parasite el ...[more]

PMID: 35573190

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Dataset Information

Plasmodium parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.

Publications

<i>Plasmodium</i> parasitophorous vacuole membrane-resident protein UIS4 manipulates host cell actin to avoid parasite elimination.

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