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In silico mutational analysis of ACE2 to check the susceptibility of lung cancer patients towards COVID-19.

ABSTRACT: Being the second major cause of death worldwide, lung cancer poses a significant threat to the health of patients. This worsened during the era of pandemic since lung cancer is found to be more prone to SARS-CoV-2 infection. Many recent studies imply a high frequency of COVID-19 infection associated severe outcome. However, molecular studies are still lacking in this respect. Hence the current study is designed to investigate the binding affinities of ACE2 lung cancer mutants with the viral spike protein to find the susceptibility of respective mutants carrying patients in catching the virus. Quite interestingly, our study found lesser binding affinities of all the selected mutants thus implying that these cancer patients might be less affected by the virus than others. These results are opposed to the recent studies' propositions and open new avenues for more in-depth studies.

SUBMITTER: Khalid Z

PROVIDER: S-EPMC9098448 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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In silico mutational analysis of ACE2 to check the susceptibility of lung cancer patients towards COVID-19.

Khalid Zumama Z Khan Abeedha Tu-Allah AT Alnajjar Radwan R Santali Eman E Shakoori Abdul Rauf AR

Scientific reports 20220512 1

Being the second major cause of death worldwide, lung cancer poses a significant threat to the health of patients. This worsened during the era of pandemic since lung cancer is found to be more prone to SARS-CoV-2 infection. Many recent studies imply a high frequency of COVID-19 infection associated severe outcome. However, molecular studies are still lacking in this respect. Hence the current study is designed to investigate the binding affinities of ACE2 lung cancer mutants with the viral spik ...[more]

PMID: 35552474

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Investigating the ACE2 polymorphisms in COVID-19 susceptibility: An in silico analysis.

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| S-EPMC7871107 | biostudies-literature

Comprehensive in silico identification of impacts of <i>ACE2</i> SNPs on COVID-19 susceptibility in different populations.

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2020-10-28 | GSE158127 | GEO

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| S-EPMC8955736 | biostudies-literature

Lions, tigers and kittens too: ACE2 and susceptibility to COVID-19.

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