Photophysical characterization and fluorescence cell imaging applications of 4-N-substituted benzothiadiazoles.

ABSTRACT: In this work, a series of fluorescent 2,1,3-benzothiadiazole derivatives with various N-substituents in the 4-position was synthesized and photophysically characterized in various solvents. Three compounds emerged as excellent fluorescent probes for imaging lipid droplets in cancer cells. A correlation between their high lipophilicity and lipid droplet specificity could be found, with log P ≥ 4 being characteristic for lipid droplet accumulation.

SUBMITTER: Doloczki S 

PROVIDER: S-EPMC9101220 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature