High-Dose versus Low-Dose Corticosteroids in COVID-19 Patients: a Systematic Review and Meta-analysis.

ABSTRACT:

Objectives

The clinical efficacy of corticosteroids remains unclear. The primary aim of this systematic review and meta-analysis was to evaluate the use of high-dose versus low- dose corticosteroids on the mortality rate of COVID-19 patients.

Design

Systematic review and meta-analysis.

Setting

Electronic search for randomized controlled trials and observational studies (MEDLINE, EMBASE, CENTRAL).

Participants

Hospitalized adults ≥ 18 years old who were SARS-CoV-2 PCR positive.

Interventions

High-dose and low-dose corticosteroids.

Measurements and main results

A total of twelve studies (n=2759 patients) were included in this review. The pooled analysis demonstrated no significant difference in mortality rate between the high-dose and low-dose corti

SUBMITTER: Tan RSJ 

PROVIDER: S-EPMC9101704 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature