Intestinal ELF4 Deletion Exacerbates Alcoholic Liver Disease by Disrupting Gut Homeostasis.

ABSTRACT: Alcohol liver disease (ALD) is characterized by intestinal barrier disruption and gut dysbiosis. Dysfunction of E74-like ETS transcription factor 4 (ELF4) leads to colitis. We aimed to test the hypothesis that intestinal ELF4 plays a critical role in maintaining the normal function of intestinal barrier and gut homeostasis in a mouse model of ALD. Intestinal ELF4 deficiency resulted in dysfunction of the intestinal barrier. Elf4^-/- mice exhibited gut microbiota (GM) dysbiosis with the characteristic of a larger proportion of Proteobacteria. The LPS increased in Elf4^-/- mice and was the most important differential metabolite between Elf4^-/- mice and WT mice. Alcohol exposure increased liver-to-body weight ratio, and hepatic inflammation

SUBMITTER: Liu T 

PROVIDER: S-EPMC9102452 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature