Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study.

ABSTRACT:

Background

Rett syndrome (RTT) is a neurodevelopmental disorder most often related to a pathogenic variant in the X-linked MECP2 gene. Internalizing behaviors appear to be common, but standard methods of diagnosing anxiety are not readily applied in this population which typically has cognitive impairment and limited expressive language. This study aims to describe the frequency of anxiety-like behavior and anxiolytic treatments along with associated clinical features in individuals with RTT.

Methods

Parental reports and medication logs provided data from 1380 females with RTT participating in two iterations of the multicenter U.S. RTT Natural History Study (RNHS) from 2006 to 2019.

Results

Most participants with RTT (77.5%) had at least occasional anxious or nervous

SUBMITTER: Buchanan CB 

PROVIDER: S-EPMC9107202 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature