Dataset Information

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults.

ABSTRACT:

Background

Low-density lipoprotein:high-density lipoprotein cholesterol ratio (LDL:HDL ratio) has a good performance in identifying diabetes mellitus (DM) and insulin resistance. However, it is not yet clear whether the LDL:HDL ratio is associated with a high-risk state of prediabetes.

Methods

This cohort study retrospectively analyzed the data of 100,309 Chinese adults with normoglycemia at baseline. The outcome event of interest was new-onset prediabetes. Using multivariate Cox regression and smoothing splines to assess the association of LDL:HDL ratio with prediabetes.

Results

During an average observation period of 37.4 months, 12,352 (12.31%) subjects were newly diagnosed with prediabetes. After adequate adjustment for important risk factors, the LDL:HDL ratio was positively correlated with the prediabetes risk, and the sensitivity analysis further suggested the robustness of the results. Additionally, in stratified analysis, we discovered significant interactions between LDL:HDL ratio and family history of DM, sex, body mass index and age (all P-interaction < 0.05); among them, the LDL:HDL ratio-related prediabetes risk decreased with the growth of body mass index and age, and increased significantly in women and people with a family history of DM.

Conclusions

The increased LDL:HDL ratio in the Chinese population indicates an increased risk of developing prediabetes, especially in women, those with a family history of DM, younger adults, and non-obese individuals.

SUBMITTER: Kuang M

PROVIDER: S-EPMC9107720 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Publications

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults.

Kuang Maobin M Peng Nan N Qiu Jiajun J Zhong Yanjia Y Zou Yang Y Sheng Guotai G

Lipids in health and disease 20220515 1

<h4>Background</h4>Low-density lipoprotein:high-density lipoprotein cholesterol ratio (LDL:HDL ratio) has a good performance in identifying diabetes mellitus (DM) and insulin resistance. However, it is not yet clear whether the LDL:HDL ratio is associated with a high-risk state of prediabetes.<h4>Methods</h4>This cohort study retrospectively analyzed the data of 100,309 Chinese adults with normoglycemia at baseline. The outcome event of interest was new-onset prediabetes. Using multivariate Cox ...[more]

PMID: 35570291

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Dataset Information

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults.

Background

Methods

Results

Conclusions

Publications

Association of LDL:HDL ratio with prediabetes risk: a longitudinal observational study based on Chinese adults.

Similar Datasets

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