Vitamin D, skin filaggrin, allergic sensitization, and race.

ABSTRACT:

Background

In addition to its involvement in both the innate and adaptive immune systems, vitamin D has been found to affect keratinocyte function and proliferation, suggesting a possible role for vitamin D in cutaneous allergic sensitization.

Objective

To explore the role of circulating vitamin D levels in allergic sensitization.

Methods

Serum 25-hydroxyvitamin D (25(OH)D) levels were measured in a subset of children (N = 323) enrolled in the Mechanisms of Progression of Atopic Dermatitis to Asthma in Children cohort, a prospective early life cohort of children with atopic dermatitis. Allergic sensitization was determined using skin prick testing, and FLG expression in the keratinocytes was measured by quantitative polymerase chain reaction. Multiple Poisson regressi

SUBMITTER: Johansson E 

PROVIDER: S-EPMC9109635 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature