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Synthesis of enol phosphates directly from ketones via a modified one-pot Perkow reaction.

ABSTRACT: A modified Perkow reaction, named Perkow-Shi reaction, was developed based on the one-pot α-tosyloxylation of ketones following by addition of P(iii)-reagents and 4 Å molecular sieves. Diversity of enol phosphates, as well as enol phosphonates, enol phosphinates, and enol phosphoramidates were synthesized in high yields directly from the ubiquitously available ketones instead of the unfavourable α-chloroketones under a mild and environmental friendly condition.

SUBMITTER: Guo H

PROVIDER: S-EPMC9112406 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Synthesis of enol phosphates directly from ketones <i>via</i> a modified one-pot Perkow reaction.

Guo Huichuang H Zhang Yulong Y Li Zhenya Z Zhao Peichao P Li Ning N Shi Enxue E

RSC advances 20220517 23

A modified Perkow reaction, named Perkow-Shi reaction, was developed based on the one-pot α-tosyloxylation of ketones following by addition of P(iii)-reagents and 4 Å molecular sieves. Diversity of enol phosphates, as well as enol phosphonates, enol phosphinates, and enol phosphoramidates were synthesized in high yields directly from the ubiquitously available ketones instead of the unfavourable α-chloroketones under a mild and environmental friendly condition. ...[more]

PMID: 35702246

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