One-Pot Synthesis of Thio-Augmented Sulfonylureas via a Modified Bunte's Reaction.

ABSTRACT: We report the development of a one-pot Bunte's reaction-enabled expeditious platform under aqueous conditions for the scalable conversion of sulfonylureas to synthetically versatile thio-sulfonylureas. The reaction was further propagated in the same pot to yield diverse chiral and achiral isothiosulfonyl analogs. The protocol enabled the synthesis of various drug-like molecules and was applied to an enantiomeric synthesis of a cannabinoid receptor antagonist SLV326.

SUBMITTER: Iyer MR 

PROVIDER: S-EPMC9453971 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature