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Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis.

ABSTRACT:

Background

Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis.

Methods

Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008-2020, were retrospectively identified.

Results

Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had positive stool samples with persisting symptoms after quinacrine treatment (94% parasitological efficacy) and all were cured after a second treatment. One (1.9%) had mild adverse effects recorded.

Conclusions

Quinacrine is an effective treatment for nitroimidazole-refractory giardiasis with good tolerability.

SUBMITTER: Ydsten KA

PROVIDER: S-EPMC9113433 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Quinacrine Treatment of Nitroimidazole-Refractory Giardiasis.

Ydsten Karin A KA Hellgren Urban U Asgeirsson Hilmir H

The Journal of infectious diseases 20220501 10

<h4>Background</h4>Limited evidence exists on efficacy and tolerability of quinacrine for nitroimidazole-refractory giardiasis.<h4>Methods</h4>Nitroimidazole-refractory giardiasis cases, defined as microbiologically (microscopy and/or PCR) confirmed treatment failure after 2 courses, during 2008-2020, were retrospectively identified.<h4>Results</h4>Of 87 patients, 54 (62%) had visited India. Quinacrine was used in 54 (62%); 51 received monotherapy and 3 combined with metronidazole. Only 3 had po ...[more]

PMID: 34036328

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