Directing group assisted rhodium catalyzed meta-C-H alkynylation of arenes.

ABSTRACT: Site-selective C-H alkynylation of arenes to produce aryl alkynes is a highly desirable transformation due to the prevalence of aryl alkynes in various natural products, drug molecules and in materials. To ensure site-selective C-H functionalization, directing group (DG) assisted C-H activation has been evolved as a useful synthetic tool. In contrast to DG-assisted ortho-C-H activation, distal meta-C-H activation is highly challenging and has attracted significant attention in recent years. However, developments are majorly focused on Pd-based catalytic systems. In order to diversify the scope of distal meta-C-H functionalization, herein we disclosed the first Rh(i) catalyzed meta-C-H alkynylation protocol through the inverse Sonogashira coupling reaction. The p

SUBMITTER: Sasmal S 

PROVIDER: S-EPMC9116288 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature