High dose chemoradiotherapy increases chance of organ preservation with satisfactory functional outcome for rectal cancer.

ABSTRACT:

Background

High dose chemoradiotherapy offers a curative chance for patients with rectal cancer that are unfit or unwilling to undergo surgical resection, yet its long-term survival and functional outcomes have been rarely investigated.

Methods

Patients with non-metastatic rectal adenocarcinoma who received pelvic radiation for curative intent from April 2006 to July 2017 were retrospectively investigated. Survival rates were analyzed using the Kaplan-Meier method. Quality of life and functional outcomes were evaluated using the EORTC quality of life questionnaire.

Results

A total of 57 patients were included, with a median age of 59.0 (range, 29-84) years. The numbers of patients who were diagnosed as stage I, II and III were 5 (8.8%), 16 (28.1%) and 36 (63.2%), resp

SUBMITTER: Wang QX 

PROVIDER: S-EPMC9118735 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature