Dataset Information

Inter- and intra-individual variability of active glucagon-like peptide 1 among healthy adults.

ABSTRACT:

Objective

To determine whether sex, age, and body mass index are correlated with active glucagon-like-peptide 1 concentrations and to investigate glucagon-like-peptide 1 reproducibility during repeated oral glucose tolerance tests.

Methods

Sixty-one healthy volunteers underwent four 2-hour repeated oral glucose tolerance tests approximately 1 week apart. Because this randomized same-subject crossover trial was designed to investigate effects of non-nutritive sweeteners, participants received 355 mL (12 ounces) of water or a beverage containing non-nutritive sweeteners 10 minutes prior to each oral glucose tolerance test. Blood samples were collected 10 minutes before, and 0, 10, 20, 30, 60, 90, and 120 minutes following ingestion of 75 grams of glucose.

Results

Basal active glucagon-like-peptide 1, peak glucagon-like-peptide 1, and glucagon-like-peptide 1 area-under-the-curve were higher in men than women (all p ≤0.04), adjusting for body mass index and age. Fasting and stimulated active glucagon-like-peptide 1 results were highly reproducible with little within-subject variability (between-subjects to within-subject variability ratio 4.2 and 3.5 for fasting glucagon-like-peptide 1 and glucagon-like-peptide 1 area-under-the-curve).

Conclusion

Men had higher active glucagon-like-peptide 1 concentrations than women. In contrast to considerable inter-individual variability of basal and stimulated active glucagon-like-peptide 1 concentrations, intra-individual variability was low, consistent with tight physiological regulation.

SUBMITTER: Sylvetsky AC

PROVIDER: S-EPMC9119643 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Inter- and intra-individual variability of active glucagon-like peptide 1 among healthy adults.

Sylvetsky A C AC Bauman V V Abdelhadi J J Blau J E JE Wilkins K J KJ Rother K I KI

Journal of translational science 20200616 6

<h4>Objective</h4>To determine whether sex, age, and body mass index are correlated with active glucagon-like-peptide 1 concentrations and to investigate glucagon-like-peptide 1 reproducibility during repeated oral glucose tolerance tests.<h4>Methods</h4>Sixty-one healthy volunteers underwent four 2-hour repeated oral glucose tolerance tests approximately 1 week apart. Because this randomized same-subject crossover trial was designed to investigate effects of non-nutritive sweeteners, participan ...[more]

PMID: 35601187

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Dataset Information

Inter- and intra-individual variability of active glucagon-like peptide 1 among healthy adults.

Objective

Methods

Results

Conclusion

Publications

Inter- and intra-individual variability of active glucagon-like peptide 1 among healthy adults.

Similar Datasets

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