Hepatic pannexin-1 mediates ST2⁺ regulatory T cells promoting resolution of inflammation in lipopolysaccharide-induced endotoxemia.

ABSTRACT: Sepsis remains the most lethal infectious disease and substantially impairs patient prognosis after liver transplantation (LT). Our previous study reported a role of the pannexin 1 (PANX1)-interleukin-33 (IL-33) axis in activating innate immunity to protect against methicillin-resistant Staphylococcus aureus infection; however, the role of PANX1 in regulating adaptive immunity in sepsis and the underlying mechanism are unclear. In this study, we examined the role of the PANX1-IL-33 axis in protecting against sepsis caused by a gram-negative bacterial infection in an independent LT cohort. Next, in animal studies, we assessed the immunological state of Panx1^-/- mice with lipopolysaccharide (LPS)-induced endotoxemia and then focused on the cytokine storm and regulatory T cells (Tr

SUBMITTER: Wang P 

PROVIDER: S-EPMC9121315 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature