Evidence of histone modification affecting ARID1A expression in colorectal cancer cell lines.

ABSTRACT:

Aim

The current study aimed to focus on the role of histone deacetylation in reduced ARID1A expression in colorectal cancer cell lines.

Background

ARID1A, a subunit of the switch/sucrose nonfermentable chromatin remodeling complex, has emerged as a bona fide tumor suppressor and is frequently downregulated and inactivated in multiple human cancers. Epigenetic modifications play an important role in dysregulation of gene expression in cancer. DNA methylation has been reported as an important regulator of ARID1A expression in colorectal cancer cell lines; however, the histone modification role in ARID1A suppression in colorectal cancer remains unclear.

Methods

The expression levels of ARID1A mRNA were determined using real-time quantitative PCR in c

SUBMITTER: Erfani M 

PROVIDER: S-EPMC9123641 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature