Sex differences in the relationships between body composition, fat distribution, and mitochondrial energy metabolism: a pilot study.

ABSTRACT:

Background

Adiposity and mitochondrial dysfunction are related factors contributing to metabolic disease development. This pilot study examined whether in vivo and ex vivo indices of mitochondrial metabolism were differentially associated with body composition in males and females.

Methods

Thirty-four participants including 19 females (mean 27 yr) and 15 males (mean 29 yr) had body composition assessed by dual energy x-ray absorptiometry and magnetic resonance (MR) imaging. Monocyte reserve capacity and maximal oxygen consumption rate (OCR) were determined ex vivo using extracellular flux analysis. In vivo quadriceps mitochondrial function was measured using ³¹P-MR spectroscopy based on post-exercise recovery kinetics (τPCr). The homeostatic model assessment of in

SUBMITTER: Bellissimo MP 

PROVIDER: S-EPMC9123728 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature