Discovery of new drug indications for COVID-19: A drug repurposing approach.

ABSTRACT:

Motivation

The outbreak of coronavirus health issues caused by COVID-19(SARS-CoV-2) creates a global threat to public health. Therefore, there is a need for effective remedial measures using existing and approved therapies with proven safety measures has several advantages. Dexamethasone (Pubchem ID: CID0000005743), baricitinib(Pubchem ID: CID44205240), remdesivir (PubchemID: CID121304016) are three generic drugs that have demonstrated in-vitro high antiviral activity against SARS-CoV-2. The present study aims to widen the search and explore the anti-SARS-CoV-2 properties of these potential drugs while looking for new drug indications with optimised benefits via in-silico research.

Method

Here, we designed a unique drug-similarity model to repurpose existing drugs against SA

SUBMITTER: Kumari P 

PROVIDER: S-EPMC9129022 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature