Early Radiographic Progression of Scleroderma: Lung Disease Predicts Long-term Mortality.

ABSTRACT:

Background

Radiographic end points commonly are included in therapeutic trials for systemic sclerosis (SSc)-interstitial lung disease (ILD); however, the relationship between these outcomes and long-term mortality is unclear.

Research question

Do short-term changes in radiographic measures of ILD predict long-term survival in patients with SSc?

Study design and methods

The Scleroderma Lung Study (SLS) I and II evaluated the safety and efficacy of cyclophosphamide (in SLS I and II) and mycophenolate mofetil (in SLS II) for the treatment of SSc-ILD. Changes in the extent of ILD over time were assessed on high-resolution CT scans of the chest by quantitative image analysis, an approach that applies a computer-based algorithm to assess changes in the radiographic extent o

SUBMITTER: Volkmann ER 

PROVIDER: S-EPMC9131045 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature