Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation.

ABSTRACT: Stem cells from human exfoliated deciduous teeth (SHED) uniquely exhibit high proliferative and neurogenic potential. Charged biomaterials have been demonstrated to promote neural differentiation of stem cells, but the dose-response effect of electrical stimuli from these materials on neural differentiation of SHED remains to be elucidated. Here, by utilizing different annealing temperatures prior to corona poling treatment, BaTiO₃/P(VDF-TrFE) ferroelectric nanocomposite membranes with varying charge polarization intensity (d ₃₃ ≈ 0, 4, 12 and 19 pC N^-1) were fabricated. Enhanced expression of neural markers, increased cell elongation and more prominent neurite outgrowths were observed with increasing surface charge of the nanocomposite membrane indi

SUBMITTER: Li X 

PROVIDER: S-EPMC9131252 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature