Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC9132077 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Chemical science 20220425 20
The transient directing group (TDG) strategy allowed long awaited access to the direct β-C(sp<sup>3</sup>)-H functionalization of unmasked aliphatic aldehydes <i>via</i> palladium catalysis. However, the current techniques are restricted to terminal methyl functionalization, limiting their structural scopes and applicability. Herein, we report the development of a direct Pd-catalyzed methylene β-C-H arylation of linear unmasked aldehydes by using 3-amino-3-methylbutanoic acid as a TDG and 2-pyri ...[more]