Dynamics of circulating calprotectin accurately predict the outcome of moderate COVID-19 patients.

ABSTRACT:

Background

Severe COVID-19 is associated with a high circulating level of calprotectin, the S100A8/S100A9 alarmin heterodimer. Baseline calprotectin amount measured in peripheral blood at diagnosis correlates with disease severity. The optimal use of this biomarker along COVID-19 course remains to be delineated.

Methods

We focused on patients with a WHO-defined moderate COVID-19 requiring hospitalization in a medical ward. We collected plasma and serum from three independent cohorts (N = 626 patients) and measured calprotectin amount at admission. We performed longitudinal measures of calprotectin in 457 of these patients (1461 samples) and used a joint latent class mixture model in which classes were defined by age, body mass index and comorbidities to identify calprotectin

SUBMITTER: Chapuis N 

PROVIDER: S-EPMC9132728 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature