Comparison of transient and permanent LAD ligation in mice using 18F-FDG PET imaging.

ABSTRACT:

Objective

Animal models for myocardial injuries represent important cornerstones in cardiovascular research to monitor the pathological processes and therapeutic approaches. We investigated the association of 18F-FDG derived left ventricular metabolic volume (LVMV), defect area and cardiac function in mice after permanent or transient ligation of the left anterior descending artery (LAD).

Methods

Serial non-invasive ECG-gated 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography (18F-FDG PET) after permanent or transient LAD ligation enabled a longitudinal in vivo correlation of 18F-FDG derived left ventricular metabolic volume to functional parameters and myocardial defect.

Results

The LVMV shows a more prominent drop after permanent than transient LAD ligatio

SUBMITTER: Fischer M 

PROVIDER: S-EPMC9132804 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature