Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study.

ABSTRACT:

Aim

Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis.

Materials & methods

A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system.

Results

A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM.

Conclusion

CEC detection has a prognostic value in GB cases at diagnosis.

SUBMITTER: Vaz Salgado MA 

PROVIDER: S-EPMC9136629 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature