Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study.
Ontology highlight
ABSTRACT: Aim
Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis.Materials & methods
A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system.Results
A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and >40 CEC/4 ml blood. Median overall survival was 25.33 months for group 1 and 8.23 months for group 2 cases (p = 0.02). There was no correlation between CEC and PWI (perfusion-weighted imaging) RM.Conclusion
CEC detection has a prognostic value in GB cases at diagnosis.
SUBMITTER: Vaz Salgado MA
PROVIDER: S-EPMC9136629 | biostudies-literature | 2022 Mar
REPOSITORIES: biostudies-literature
Publications
Prognostic value of circulating endothelial cells in glioblastoma patients: a pilot study.
Vaz Salgado María Angeles MA Earl Julie J Berrocal Victor Rodriguez VR Arrieta Freddy Salge FS Gomez Ana A Sepulveda-Sanchez Juan Manuel JM Perez-Nuñez Ángel Á de la Fuente Elena Corral EC Lourido Daniel D Villamayor María M Pian Hector H Muriel Alfonso A Rossi Elisabetta E Zamarchi Rita R Carrato Alfredo A Ley Luis L
Future science OA 20220301 5
<h4>Aim</h4>Glioblastoma (GB) is an aggressive tumor type and the detection of circulating endothelial cells (CECs) in peripheral blood has been related to angiogenesis.<h4>Materials & methods</h4>A prospective single-center pilot study of CEC detection at diagnosis in 22 patients with GB was performed, using the US FDA-approved CellSearch system.<h4>Results</h4>A CEC cutoff value was estimated using a receiver operating curve (ROC) and patients were classified into two groups: <40 CEC/4 ml and ...[more]
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