Clinical Events and Renal Function in the First Year Predict Long-Term Kidney Transplant Survival.

ABSTRACT:

Background

Estimated glomerular filtration rate (eGFR) at 1 year post transplantation has been shown to be a strong predictor of long-term graft survival. However, intercurrent events (ICEs) may affect the relationship between eGFR and failure risk.

Methods

The OPTN and USRDS databases on single-organ kidney transplant recipients from 2012 to 2016 were linked. Competing risk regressions estimated adjusted subhazard ratios (SHRs) of 12-month eGFR on long-term graft failure, considering all-cause mortality as the competing risk, for deceased donor (DD) and living donor (LD) recipients. Additional predictors included recipient, donor, and transplant characteristics. ICEs examined were acute rejection, cardiovascular events, and infections.

Results

Cohorts comprised 25,13

SUBMITTER: Schold JD 

PROVIDER: S-EPMC9136886 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature