A sequential allocation study to determine the ED₅₀ of Dexmedetomidine as an adjuvant to lidocaine intravenous regional anesthesia.

ABSTRACT:

Background

Intravenous regional anesthesia is an easy and reliable anesthetic technique, but its use is limited by tourniquet pain. Clonidine is effective in overcoming this shortcoming when used with intravenous regional anesthesia at a dose of 1 μg/kg. Dexmedetomidine has also been used successfully at a dose of 0.5 μg/kg.

Objective

Based on the potency ratios of clonidine and dexmedetomidine (8 to 1) we hypothesize that a lower dexmedetomidine dose would provide patients with 50 min of pain free tourniquet time.

Methods

After informed consent, patients received intravenous regional anesthesia with lidocaine and dexmedetomidine following a sequential allocation scheme. The first patient received a dose of 0.5 μg/kg of dexmedetomidine. The dose was then adjusted in 0

SUBMITTER: Karam C 

PROVIDER: S-EPMC9137144 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature