Ontology highlight
ABSTRACT:
SUBMITTER: Bryan EJ
PROVIDER: S-EPMC9137614 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Bryan Eric J EJ Sagong Hye Yeon HY Parhi Ajit K AK Grier Mark C MC Roberge Jacques Y JY LaVoie Edmond J EJ Pilch Daniel S DS
Antibiotics (Basel, Switzerland) 20220520 5
The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongasome protein in most Gram-negative bacterial rods. Here, we describe a third-generation MreB inhibitor (TXH11106) with enhanced bactericidal activity versus the Gram-negative pathogens <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, <i>Acinetoba ...[more]