Amyloid Beta Oligomers-Induced Ca²⁺ Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation.

ABSTRACT: The molecular basis of amyloid toxicity in Alzheimer's disease (AD) remains controversial. Amyloid β (Aβ) oligomers promote Ca²⁺ influx, mitochondrial Ca²⁺ overload and apoptosis in hippocampal neurons in vivo and in vitro, but the primary Ca²⁺ entry pathways are unclear. We studied Ca²⁺ entry pathways induced by Aβ oligomers in rat hippocampal and cerebellar neurons. Aβ oligomers induce Ca²⁺ entry in neurons. Ca²⁺ responses to Aβ oligomers are large after synaptic networking and prevented by blockers of synaptic transmission. In contrast, in neurons devoid of synaptic connections, Ca²⁺ responses to Aβ oligomers are small and prevented only by blockers of amyloid channels (NA7) and NMDA receptors (MK801). A combin

SUBMITTER: Caballero E 

PROVIDER: S-EPMC9138537 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature