Chitosan-Based Materials Featuring Multiscale Anisotropy for Wider Tissue Engineering Applications.

ABSTRACT: We designed graphene oxide composites with increased morphological and structural variability using fatty acid-coupled polysaccharide co-polymer as the continuous phase. The matrix was synthesized by N, O-acylation of chitosan with palmitic and lauric acid. The obtained co-polymer was crosslinked with genipin and composited with graphene oxide. FTIR spectra highlighted the modification and multi-components interaction. DLS, SEM, and contact angle tests demonstrated that the conjugation of hydrophobic molecules to chitosan increased surface roughness and hydrophilicity, since it triggered a core-shell macromolecular structuration. Nanoindentation revealed a notable durotaxis gradient due to chitosan/fatty acid self-organization and graphene sheet embedment. The composited building blocks wi

SUBMITTER: Vlasceanu GM 

PROVIDER: S-EPMC9140409 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature